2025 NFL Week 1 Betting Odds and Key Matchups: Full Schedule Analysis
Explore the 2025 NFL Week 1 schedule with detailed betting odds, key matchups, and expert analysis for every game. Don't miss the season opener!
The 2025 NFL season is set to kick off with an exciting Week 1 schedule, and the betting odds are already generating buzz among fans and analysts alike. Here’s a comprehensive breakdown of the opening games, key matchups, and betting lines to watch.
Season Opener: Eagles vs. Cowboys
The defending Super Bowl champions, the Philadelphia Eagles, will start their title defense against the Dallas Cowboys on Thursday, September 4. The Eagles are favored by 7 points, with a money line of -300, while the Cowboys are at +250. The total points line is set at 46.5.
Highlighted Matchups
- Kansas City Chiefs vs. Los Angeles Chargers: The Chiefs are slight favorites at -2.5, with a money line of -155. This game will be played in São Paulo, Brazil, marking an exciting international showdown.
- Baltimore Ravens vs. Buffalo Bills: This Sunday night game features the highest points total of Week 1 at 51.5. The Bills are favored by 1.5 points at home.
- Detroit Lions vs. Green Bay Packers: A classic NFC North rivalry kicks off at Lambeau Field, with the Lions favored by 1.5 points.
Key Betting Trends
- Washington Commanders (-7.5) vs. New York Giants: The Commanders have the largest spread of Week 1, favored by 7.5 points.
- Eleven Games with Tight Spreads: Over half of the Week 1 games have spreads of a field goal or less, indicating highly competitive matchups.
International Games
The NFL continues its global expansion with games in Dublin, London, Berlin, and Madrid. Notable international matchups include:
- Minnesota Vikings vs. Pittsburgh Steelers in Dublin on September 28.
- Denver Broncos vs. New York Jets in London on October 12.
Betting Tips
- Look for Value in Underdogs: With so many tight spreads, underdogs like the Cowboys (+250) and Giants (+300) could offer significant value.
- Monitor Line Movements: Odds can shift as game day approaches, so stay updated for the best betting opportunities.
For the latest odds and expert analysis, visit ESPN BET.
Full Week 1 Schedule
| Date | Matchup | Spread | Money Line | Total |
|---|---|---|---|---|
| Thu, Sept 4 | Cowboys at Eagles | Eagles -7 | Eagles -300 | 46.5 |
| Fri, Sept 5 | Chiefs at Chargers | Chiefs -2.5 | Chiefs -155 | 44.5 |
| Sun, Sept 7 | Giants at Commanders | Commanders -7.5 | Commanders -400 | 45.5 |
| Sun, Sept 7 | Buccaneers at Falcons | Buccaneers -1.5 | Buccaneers -135 | 48.5 |
| Sun, Sept 7 | Panthers at Jaguars | Jaguars -2.5 | Jaguars -165 | 45.5 |
| Sun, Sept 7 | Dolphins at Colts | Colts -1 | Colts -120 | 45.5 |
| Sun, Sept 7 | Raiders at Patriots | Patriots -2 | Patriots -135 | 43.5 |
| Sun, Sept 7 | Steelers at Jets | Steelers -2.5 | Steelers -155 | 39.5 |
| Sun, Sept 7 | Bengals at Browns | Bengals -5 | Bengals -240 | 44.5 |
| Sun, Sept 7 | Cardinals at Saints | Cardinals -4.5 | Cardinals -195 | 41.5 |
| Sun, Sept 7 | 49ers at Seahawks | 49ers -1.5 | 49ers -125 | 45.5 |
| Sun, Sept 7 | Titans at Broncos | Broncos -7 | Broncos -320 | 41.5 |
| Sun, Sept 7 | Lions at Packers | Lions -1.5 | Lions -115 | 49.5 |
| Sun, Sept 7 | Texans at Rams | Rams -2.5 | Rams -145 | 46.5 |
| Mon, Sept 8 | Vikings at Bears | Bears -1 | Bears -110 | 45.5 |
Get ready for an action-packed start to the 2025 NFL season!
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